Kisspeptin
Kisspeptin is a neuropeptide acting on GPR54 receptors, studied as an upstream regulator of the hypothalamic-pituitary-gonadal axis in reproductive endocrinology research. It is a critical compound for investigating GnRH neuron activation and HPG axis signaling cascades. For research purposes only.
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Research Overview
Kisspeptin is a neuropeptide encoded by the KISS1 gene that serves as a critical upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It acts through the kisspeptin receptor (KISS1R/GPR54) to stimulate gonadotropin-releasing hormone (GnRH) neurons. Kisspeptin research has fundamental implications for understanding reproductive endocrinology, puberty onset, and fertility.
Mechanism of Action
Kisspeptin binds to the KISS1R receptor (GPR54) on GnRH neurons in the hypothalamus, triggering robust GnRH secretion. This downstream cascade stimulates pituitary release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Kisspeptin is considered the master regulator of reproductive hormone signaling, integrating metabolic, circadian, and stress signals into HPG axis control. It is essential for normal puberty initiation and maintenance of adult reproductive function.
Experimental Applications
Studied in reproductive neuroendocrinology, GnRH pulse generator characterization, LH/FSH secretion dynamics, puberty onset timing research, fertility and ovulation studies, metabolic-reproductive axis interactions, and hypothalamic neuron mapping.
Compound Information
Technical specifications
What is Kisspeptin-10?
| Type | Synthetic Peptide (KiSS-1 derived) |
| CAS Number | 374675-21-5 |
| Molecular Weight | 1,302.44 g/mol |
| Amino Acids | 10 |
| Molecular Formula | C₆₃H₈₃N₁₇O₁₄ |
Stability Information
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Estimated plasma concentration over time
Compound Specifications
| Compound Type | Neuropeptide (KISS1 gene product) |
| Purity | ≥ 99% |
| Appearance | White lyophilized powder |
| Storage | -20°C long-term; 2-8°C short-term |
| Testing Methods | HPLC, Mass Spectrometry |
| Packaging | Sealed sterile vial |
Certificate of Analysis
Lab Testing Notes
Third-party verified via HPLC for purity and Mass Spectrometry for molecular identity. Sequence integrity confirmed. COA available on this page.
Mechanism of Action
Kisspeptin binds to the KISS1R receptor (GPR54) on GnRH neurons in the hypothalamus, triggering robust GnRH secretion. This downstream cascade stimulates pituitary release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Kisspeptin is considered the master regulator of reproductive hormone signaling, integrating metabolic, circadian, and stress signals into HPG axis control. It is essential for normal puberty initiation and maintenance of adult reproductive function.
Experimental Applications
Studied in reproductive neuroendocrinology, GnRH pulse generator characterization, LH/FSH secretion dynamics, puberty onset timing research, fertility and ovulation studies, metabolic-reproductive axis interactions, and hypothalamic neuron mapping.
Reconstitution Guidelines
Reconstitute with bacteriostatic water. Inject slowly along the vial wall. Gently swirl to dissolve. Do not shake. Recommended: 1 mL per vial. Store at 2–8°C. Use within 21 days.
Sources & References
Peer-reviewed research
Kisspeptin-10 Potently Stimulates LH and GnRH in Humans
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