GLP-3RT
GLP-3RT is a novel triple-agonist peptide targeting GLP-1, GIP, and glucagon receptors simultaneously in research settings. As the first compound of its kind available for laboratory investigation, it enables study of the complex interplay between three metabolic signaling pathways. For research purposes only.
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Research Overview
GLP-3RT is a novel triple agonist peptide that simultaneously activates GIP, GLP-1, and glucagon receptors. It represents the first investigational "triagonist" in its class. Phase 2 clinical trial data published in the New England Journal of Medicine demonstrated unprecedented efficacy in metabolic research endpoints, making it one of the most significant incretin-class compounds currently under investigation.
Mechanism of Action
GLP-3RT engages three distinct receptor systems: GLP-1R (glucagon-like peptide-1 receptor) — enhances insulin secretion, slows gastric emptying, and acts on hypothalamic appetite centers. GIPR (glucose-dependent insulinotropic polypeptide receptor) — potentiates insulin response and improves lipid metabolism. GCGR (glucagon receptor) — increases energy expenditure, promotes hepatic fat oxidation, and stimulates thermogenesis. The triple mechanism provides complementary metabolic effects beyond what dual agonists achieve.
Experimental Applications
Research applications include incretin receptor pharmacology, triple agonism vs. dual agonism comparative studies, energy expenditure and thermogenesis models, hepatic lipid metabolism, glucose-stimulated insulin secretion assays, gastric emptying kinetics, and appetite regulation neurocircuitry studies.
Compound Specifications
| Compound Type | Triple Incretin Receptor Agonist (GLP-1/GIP/Glucagon) |
| Purity | ≥ 99% |
| Appearance | White lyophilized powder |
| Storage | -20°C long-term; 2-8°C short-term |
| Testing Methods | HPLC, Mass Spectrometry |
| Packaging | Sealed sterile vial |
Certificate of Analysis
Lab Testing Notes
Each batch verified by independent third-party labs via HPLC (purity ?99%) and Mass Spectrometry (molecular weight confirmation). Full COA included with every order.
Mechanism of Action
GLP-3RT engages three distinct receptor systems: GLP-1R (glucagon-like peptide-1 receptor) — enhances insulin secretion, slows gastric emptying, and acts on hypothalamic appetite centers. GIPR (glucose-dependent insulinotropic polypeptide receptor) — potentiates insulin response and improves lipid metabolism. GCGR (glucagon receptor) — increases energy expenditure, promotes hepatic fat oxidation, and stimulates thermogenesis. The triple mechanism provides complementary metabolic effects beyond what dual agonists achieve.
Experimental Applications
Research applications include incretin receptor pharmacology, triple agonism vs. dual agonism comparative studies, energy expenditure and thermogenesis models, hepatic lipid metabolism, glucose-stimulated insulin secretion assays, gastric emptying kinetics, and appetite regulation neurocircuitry studies.
Reconstitution Guidelines
Reconstitute with bacteriostatic water. Inject slowly along the vial wall. Gently swirl until dissolved. Do not shake. Recommended: 1–2 mL per vial. Store at 2–8°C. Use within 30 days.
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