Melanotan II
Melanotan is an alpha-MSH analog investigated for MC1R receptor activation and melanogenesis pathway research. Laboratory studies focus on its role in melanocyte stimulation and the biological mechanisms governing melanin biosynthesis. For research purposes only.
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Research Overview
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analog of ?-MSH developed at the University of Arizona. Unlike the linear Melanotan 1, MT-II is a non-selective melanocortin receptor agonist, binding to MC1R, MC3R, MC4R, and MC5R. This broader receptor profile gives it a wider range of research applications across pigmentation, sexual function, appetite, and energy homeostasis.
Mechanism of Action
MT-II activates multiple melanocortin receptors: MC1R (melanogenesis/pigmentation), MC3R (energy homeostasis and inflammation), MC4R (appetite regulation and sexual function), and MC5R (exocrine gland function). The cyclic structure provides enhanced stability and receptor binding. MC4R activation in the hypothalamus triggers erectile and sexual arousal pathways, while MC1R activation stimulates melanocyte eumelanin production.
Experimental Applications
Studied in melanocortin receptor selectivity profiling, melanogenesis pathway research, MC4R-mediated appetite and feeding behavior studies, sexual function and erectile physiology models, energy balance research, and inflammatory pathway modulation via MC3R.
Compound Information
Technical specifications
What is Melanotan II?
| Type | Synthetic Peptide (MC receptor agonist) |
| CAS Number | 121062-08-6 |
| Molecular Weight | 1,024.18 g/mol |
| Amino Acids | 7 |
| Molecular Formula | C₅₀H₆₉N₁₅O₉ |
Stability Information
Loading structure…
Estimated plasma concentration over time
Compound Specifications
| Compound Type | Cyclic Heptapeptide (MC receptor agonist) |
| Purity | ≥ 99% |
| Appearance | White lyophilized powder |
| Storage | -20°C long-term; 2-8°C short-term |
| Testing Methods | HPLC, Mass Spectrometry |
| Packaging | Sealed sterile vial |
Certificate of Analysis
Lab Testing Notes
Each batch independently verified for purity (?99%) via HPLC and identity via Mass Spectrometry. Full COA available on this page.
Mechanism of Action
MT-II activates multiple melanocortin receptors: MC1R (melanogenesis/pigmentation), MC3R (energy homeostasis and inflammation), MC4R (appetite regulation and sexual function), and MC5R (exocrine gland function). The cyclic structure provides enhanced stability and receptor binding. MC4R activation in the hypothalamus triggers erectile and sexual arousal pathways, while MC1R activation stimulates melanocyte eumelanin production.
Experimental Applications
Studied in melanocortin receptor selectivity profiling, melanogenesis pathway research, MC4R-mediated appetite and feeding behavior studies, sexual function and erectile physiology models, energy balance research, and inflammatory pathway modulation via MC3R.
Reconstitution Guidelines
Reconstitute with bacteriostatic water. Inject slowly along the inner vial wall. Gently swirl until dissolved. Do not shake. Recommended: 1–2 mL per vial. Store at 2–8°C. Use within 30 days.
How Does Melanotan II Compare?
Melanocortin Peptides
| Property | Melanotan II | Melanotan I (Afamelanotide) | PT-141 (Bremelanotide) |
|---|---|---|---|
| Type | Synthetic Peptide (MC receptor agonist) | α-MSH Analog | Melanocortin Receptor Agonist |
| Molecular Weight | 1,024.18 | 1,646.85 | 1,025.17 |
| Amino Acids | 7 | 13 | 7 |
| CAS Number | 121062-08-6 | 75921-69-6 | 189691-06-3 |
| Formula | C₅₀H₆₉N₁₅O₉ | C₇₈H₁₁₁N₂₁O₁₉ | C₅₀H₆₈N₁₄O₁₀ |
| Current | View Product → | View Product → |
Commonly Researched Together
Complementary compounds frequently paired with Melanotan II in published studies
Sources & References
Peer-reviewed research
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