Sermorelin
Sermorelin is a synthetic GHRH(1-29) analog retaining full biological activity of native GHRH, widely used as a reference standard in growth hormone axis research. Studies examine GHRH receptor activation, GH pulse dynamics, and age-related changes in somatotropic function. For research purposes only.
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Research Overview
Sermorelin (GRF 1-29) is a synthetic peptide consisting of the first 29 amino acids of the 44-amino acid human growth hormone-releasing hormone (GHRH). It retains full biological activity of native GHRH and was the first GHRH analog to receive FDA approval (Geref®). Sermorelin stimulates physiological pulsatile GH release, making it a foundational tool in somatotroph axis research.
Mechanism of Action
Sermorelin binds to the GHRH receptor (GHRHR) on anterior pituitary somatotroph cells, activating the Gs-cAMP-PKA signaling cascade that triggers growth hormone gene transcription and secretory granule exocytosis. Unlike exogenous GH, Sermorelin preserves the natural pulsatile pattern of GH release and maintains hypothalamic-pituitary feedback regulation. This makes it a preferred research tool for studying endogenous GH axis physiology.
Experimental Applications
Used in GH axis stimulation testing, age-related GH decline research, pulsatile secretion pattern analysis, IGF-1 response profiling, pituitary reserve assessment models, sleep-associated GH release studies, and GHRH receptor pharmacology.
Compound Information
Technical specifications
What is Sermorelin?
| Type | GHRH Analog (1-29) |
| CAS Number | 86168-78-7 |
| Molecular Weight | 3,357.88 g/mol |
| Amino Acids | 29 |
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
Stability Information
Loading structure…
Estimated plasma concentration over time
Compound Specifications
| Compound Type | GHRH Analog (amino acids 1-29) |
| Purity | ≥ 99% |
| Appearance | White lyophilized powder |
| Storage | -20°C long-term; 2-8°C short-term |
| Testing Methods | HPLC, Mass Spectrometry |
| Packaging | Sealed sterile vial |
Certificate of Analysis
Lab Testing Notes
Third-party verified via HPLC (purity ?99%) and Mass Spectrometry. Amino acid sequence confirmed against USP reference standard. COA available on this page.
Mechanism of Action
Sermorelin binds to the GHRH receptor (GHRHR) on anterior pituitary somatotroph cells, activating the Gs-cAMP-PKA signaling cascade that triggers growth hormone gene transcription and secretory granule exocytosis. Unlike exogenous GH, Sermorelin preserves the natural pulsatile pattern of GH release and maintains hypothalamic-pituitary feedback regulation. This makes it a preferred research tool for studying endogenous GH axis physiology.
Experimental Applications
Used in GH axis stimulation testing, age-related GH decline research, pulsatile secretion pattern analysis, IGF-1 response profiling, pituitary reserve assessment models, sleep-associated GH release studies, and GHRH receptor pharmacology.
Reconstitution Guidelines
Reconstitute with bacteriostatic water. Inject slowly along the vial wall. Swirl gently — do not shake. Recommended: 1–2 mL per vial. Store at 2–8°C. Use within 30 days.
How Does Sermorelin Compare?
Growth Hormone Peptides
| Property | Sermorelin | Ipamorelin | Tesamorelin | CJC-1295 DAC |
|---|---|---|---|---|
| Type | GHRH Analog (1-29) | Growth Hormone Secretagogue | GHRH Analog | GHRH Analog (with DAC) |
| Molecular Weight | 3,357.88 | 711.85 | 5,135.68 | 3,647.15 |
| Amino Acids | 29 | 5 | 44 | 30 |
| CAS Number | 86168-78-7 | 170851-70-4 | 218949-48-5 | 863288-34-0 |
| Formula | C₁₄₉H₂₄₆N₄₄O₄₂S | C₃₈H₄₉N₉O₅ | C₂₂₁H₃₆₆N₇₂O₆₇S | C₁₆₅H₂₆₉N₄₇O₄₆ |
| Current | View Product → | View Product → | View Product → |
Commonly Researched Together
Complementary compounds frequently paired with Sermorelin in published studies
Sources & References
Peer-reviewed research
Sermorelin: A Review of Its Use in the Diagnosis and Treatment of Growth Disorders
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