Ipamorelin
Ipamorelin is a selective growth hormone secretagogue studied for its high receptor specificity in ghrelin/GHS-R pathway research. Unlike broader-acting secretagogues, it demonstrates minimal cross-reactivity with cortisol and prolactin pathways, making it a clean reference compound for GH-axis studies. For research purposes only.
Weekdays before 2PM EST
With Every Batch
Tested in USA
ACH
Zelle
Research Overview
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) and selective agonist of the ghrelin/GHS receptor (GHS-R1a). Developed by Novo Nordisk, it is distinguished from other GH secretagogues by its high selectivity — it stimulates growth hormone release without significantly elevating cortisol, ACTH, or prolactin levels, making it one of the cleanest GHS compounds in research.
Mechanism of Action
Ipamorelin binds to the GHS-R1a (ghrelin receptor) on anterior pituitary somatotroph cells, triggering intracellular calcium signaling and subsequent growth hormone exocytosis. Unlike GHRP-2 and GHRP-6, Ipamorelin does not significantly activate the HPA axis (cortisol) or lactotroph signaling (prolactin). This selectivity is attributed to its specific binding conformation that favors GH release pathways while avoiding off-target receptor activation.
Experimental Applications
Research includes selective GH secretion studies, dose-response GH pulse characterization, bone density and metabolism studies in aging models, gut motility research (GHS-R1a is expressed in the GI tract), and comparative selectivity profiling against GHRP-2, GHRP-6, and hexarelin.
Compound Information
Technical specifications
What is Ipamorelin?
| Type | Growth Hormone Secretagogue |
| CAS Number | 170851-70-4 |
| Molecular Weight | 711.85 g/mol |
| Amino Acids | 5 |
| Molecular Formula | C₃₈H₄₉N₉O₅ |
Stability Information
Loading structure…
Estimated plasma concentration over time
Compound Specifications
| Compound Type | Synthetic Pentapeptide (GHS) |
| Purity | ≥ 99% |
| Appearance | White lyophilized powder |
| Storage | -20°C long-term; 2-8°C short-term |
| Testing Methods | HPLC, Mass Spectrometry |
| Packaging | Sealed sterile vial |
Certificate of Analysis
Lab Testing Notes
Independently tested for purity (?99%) via HPLC and molecular weight verification via Mass Spectrometry. COA included with every order.
Mechanism of Action
Ipamorelin binds to the GHS-R1a (ghrelin receptor) on anterior pituitary somatotroph cells, triggering intracellular calcium signaling and subsequent growth hormone exocytosis. Unlike GHRP-2 and GHRP-6, Ipamorelin does not significantly activate the HPA axis (cortisol) or lactotroph signaling (prolactin). This selectivity is attributed to its specific binding conformation that favors GH release pathways while avoiding off-target receptor activation.
Experimental Applications
Research includes selective GH secretion studies, dose-response GH pulse characterization, bone density and metabolism studies in aging models, gut motility research (GHS-R1a is expressed in the GI tract), and comparative selectivity profiling against GHRP-2, GHRP-6, and hexarelin.
Reconstitution Guidelines
Reconstitute with bacteriostatic water. Inject slowly along the inner vial wall. Gently swirl until dissolved — do not shake. Recommended: 1–2 mL per vial. Store at 2–8°C. Use within 30 days.
How Does Ipamorelin Compare?
Growth Hormone Peptides
| Property | Ipamorelin | Sermorelin | Tesamorelin | CJC-1295 DAC |
|---|---|---|---|---|
| Type | Growth Hormone Secretagogue | GHRH Analog (1-29) | GHRH Analog | GHRH Analog (with DAC) |
| Molecular Weight | 711.85 | 3,357.88 | 5,135.68 | 3,647.15 |
| Amino Acids | 5 | 29 | 44 | 30 |
| CAS Number | 170851-70-4 | 86168-78-7 | 218949-48-5 | 863288-34-0 |
| Formula | C₃₈H₄₉N₉O₅ | C₁₄₉H₂₄₆N₄₄O₄₂S | C₂₂₁H₃₆₆N₇₂O₆₇S | C₁₆₅H₂₆₉N₄₇O₄₆ |
| Current | View Product → | View Product → | View Product → |
Commonly Researched Together
Complementary compounds frequently paired with Ipamorelin in published studies
Sources & References
Peer-reviewed research
Ipamorelin, the First Selective Growth Hormone Secretagogue
View SourceRelated Peptides
Premium research peptides, lab-tested for purity
