Ipamorelin
Ipamorelin is a selective growth hormone secretagogue studied for its high receptor specificity in ghrelin/GHS-R pathway research. Unlike broader-acting secretagogues, it demonstrates minimal cross-reactivity with cortisol and prolactin pathways, making it a clean reference compound for GH-axis studies. For research purposes only.
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Research Overview
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) and selective agonist of the ghrelin/GHS receptor (GHS-R1a). Developed by Novo Nordisk, it is distinguished from other GH secretagogues by its high selectivity — it stimulates growth hormone release without significantly elevating cortisol, ACTH, or prolactin levels, making it one of the cleanest GHS compounds in research.
Mechanism of Action
Ipamorelin binds to the GHS-R1a (ghrelin receptor) on anterior pituitary somatotroph cells, triggering intracellular calcium signaling and subsequent growth hormone exocytosis. Unlike GHRP-2 and GHRP-6, Ipamorelin does not significantly activate the HPA axis (cortisol) or lactotroph signaling (prolactin). This selectivity is attributed to its specific binding conformation that favors GH release pathways while avoiding off-target receptor activation.
Experimental Applications
Research includes selective GH secretion studies, dose-response GH pulse characterization, bone density and metabolism studies in aging models, gut motility research (GHS-R1a is expressed in the GI tract), and comparative selectivity profiling against GHRP-2, GHRP-6, and hexarelin.
Compound Specifications
| Compound Type | Synthetic Pentapeptide (GHS) |
| Purity | ≥ 99% |
| Appearance | White lyophilized powder |
| Storage | -20°C long-term; 2-8°C short-term |
| Testing Methods | HPLC, Mass Spectrometry |
| Packaging | Sealed sterile vial |
Certificate of Analysis
Lab Testing Notes
Independently tested for purity (?99%) via HPLC and molecular weight verification via Mass Spectrometry. COA included with every order.
Mechanism of Action
Ipamorelin binds to the GHS-R1a (ghrelin receptor) on anterior pituitary somatotroph cells, triggering intracellular calcium signaling and subsequent growth hormone exocytosis. Unlike GHRP-2 and GHRP-6, Ipamorelin does not significantly activate the HPA axis (cortisol) or lactotroph signaling (prolactin). This selectivity is attributed to its specific binding conformation that favors GH release pathways while avoiding off-target receptor activation.
Experimental Applications
Research includes selective GH secretion studies, dose-response GH pulse characterization, bone density and metabolism studies in aging models, gut motility research (GHS-R1a is expressed in the GI tract), and comparative selectivity profiling against GHRP-2, GHRP-6, and hexarelin.
Reconstitution Guidelines
Reconstitute with bacteriostatic water. Inject slowly along the inner vial wall. Gently swirl until dissolved — do not shake. Recommended: 1–2 mL per vial. Store at 2–8°C. Use within 30 days.
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