Selank
Selank is a synthetic heptapeptide analog of tuftsin studied for its immunomodulatory properties and GABAergic system interactions in research settings. Laboratory investigations focus on its effects on BDNF expression, neurotrophic factor modulation, and immune response signaling. For research purposes only.
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Research Overview
Selank is a synthetic heptapeptide analog of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), with a Pro-Gly-Pro stabilizing sequence added. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank has been studied extensively for its anxiolytic and nootropic properties. It is approved as a nasal spray medication in Russia for anxiety and neurasthenia.
Mechanism of Action
Selank modulates the expression and metabolism of brain-derived neurotrophic factor (BDNF) and its receptor TrkB. It affects the balance of monoamine neurotransmitters — increasing serotonin metabolism and modulating dopaminergic and noradrenergic systems. The peptide also inhibits enkephalin-degrading enzymes, prolonging endogenous opioid peptide activity. Additionally, Selank modulates IL-6 expression and NK cell activity, reflecting its tuftsin-derived immunomodulatory heritage.
Experimental Applications
Research includes BDNF expression profiling, anxiety-related behavior models (elevated plus maze, light-dark box), cognitive performance assays (Morris water maze, novel object recognition), monoamine neurotransmitter metabolism studies, immune function modulation, and gene expression studies (IL-6, enkephalin pathways).
Compound Specifications
| Compound Type | Synthetic Heptapeptide (Tuftsin analog) |
| Purity | ≥ 99% |
| Appearance | White lyophilized powder |
| Storage | -20°C long-term; 2-8°C short-term |
| Testing Methods | HPLC, Mass Spectrometry |
| Packaging | Sealed sterile vial |
Certificate of Analysis
Lab Testing Notes
Verified via HPLC (purity ?99%) and Mass Spectrometry (identity/sequence confirmation). COA provided with every batch.
Mechanism of Action
Selank modulates the expression and metabolism of brain-derived neurotrophic factor (BDNF) and its receptor TrkB. It affects the balance of monoamine neurotransmitters — increasing serotonin metabolism and modulating dopaminergic and noradrenergic systems. The peptide also inhibits enkephalin-degrading enzymes, prolonging endogenous opioid peptide activity. Additionally, Selank modulates IL-6 expression and NK cell activity, reflecting its tuftsin-derived immunomodulatory heritage.
Experimental Applications
Research includes BDNF expression profiling, anxiety-related behavior models (elevated plus maze, light-dark box), cognitive performance assays (Morris water maze, novel object recognition), monoamine neurotransmitter metabolism studies, immune function modulation, and gene expression studies (IL-6, enkephalin pathways).
Reconstitution Guidelines
Reconstitute with bacteriostatic water. Inject slowly along vial wall. Gently swirl to dissolve. Do not shake. Recommended: 1–2 mL per vial. Store at 2–8°C. Use within 30 days.
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